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Literature summary extracted from

  • Rosenthal, F.; Feijs, K.L.; Frugier, E.; Bonalli, M.; Forst, A.H.; Imhof, R.; Winkler, H.C.; Fischer, D.; Caflisch, A.; Hassa, P.O.; Luescher, B.; Hottiger, M.O.
    Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases (2013), Nat. Struct. Mol. Biol., 20, 502-507 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.106 expressed in Escherichia coli BL21 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.106 G100E the mutant isoform MacroD2 lacks hydrolase and ADP-ribose-binding activities Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.106 Homo sapiens
-
-
-
3.1.1.106 Homo sapiens A1Z1Q3
-
-
3.1.1.106 Homo sapiens Q9BQ69
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.106 Ni-Sepharose column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.106 2''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
3.1.1.106 3''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
3.1.1.106 additional information isoform MacroD1 is completely inactive toward poly-ADP-D-ribose synthesized by ADP-ribosyltransferase diphtheria toxin-like 1 in the presence of high NAD+ concentrations Homo sapiens ?
-
 ?
3.1.1.106 additional information isoform MacroD2 is a mono-ADP-ribosylhydrolase specific for acidic residues of aspartates and glutamates Homo sapiens ?
-
 ?
3.1.1.106 additional information isoform MacroD2 is completely inactive toward poly-ADP-D-ribose synthesized by ADP-ribosyltransferase diphtheria toxin-like 1 in the presence of high NAD+ concentrations. MacroD2 does not remove ADP-D-ribose modifications generated by the arginine-specific enzyme CDTa or TccC3 Homo sapiens ?
-
 ?
3.1.1.106 [ARTD10 protein]-ADP-D-ribose + H2O
-
 Homo sapiens [ARTD10 protein] + ADP-D-ribose
-
 ?
3.1.1.106 [glycogen synthase kinase 3beta]-ADP-D-ribose + H2O
-
 Homo sapiens [glycogen synthase kinase 3beta] + ADP-D-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.106 C6orf130
-
 Homo sapiens
3.1.1.106 MACROD1
-
 Homo sapiens
3.1.1.106 MacroD2
-
 Homo sapiens
3.1.1.106 mono-ADP-ribosylhydrolase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.106 physiological function isoform MacroD2 regulates GSK3beta function Homo sapiens